Nigeria governor, 5 others die in helicopter crash

LAGOS, Nigeria (AP) — A navy helicopter crashed Saturday in the country’s oil-rich southern delta, killing a state governor and five other people, in the latest air disaster to hit Africa’s most populous nation, officials said.

Nigeria‘s ruling party said in a statement that the governor of the central Nigerian state of Kaduna, Patrick Yakowa, died in the helicopter crash in Bayelsa state in the Niger Delta. The People’s Democratic Party’s statement described Yakowa’s death as a “colossal loss.”

The statement said the former national security adviser, General Andrew Azazi, also died in the crash. Azazi was fired in June amid growing sectarian violence in Nigeria, but maintained close ties with the government.

Yushau Shuaib, a spokesman for Nigeria’s National Emergency Management Agency, said four other bodies had been found, but he could not immediately give their identities.

The crash occurred at about 3:30 p.m. after the navy helicopter took off from the village of Okoroba in Bayelsa state where officials had gathered to attend the burial of the father of a presidential aide, said Commodore Kabir Aliyu. He said that the helicopter was headed for Nigeria’s oil capital of Port Harcourt when it crashed in the Nembe area of Bayelsa state.

Aviation disasters remain common in Nigeria, despite efforts in recent years to improve air safety.

In October, a plane made a crash landing in central Nigeria. A state governor and five others sustained injuries but survived.

In June, a Dana Air MD-83 passenger plane crashed into a neighborhood in the commercial capital of Lagos, killing 153 people onboard and at least 10 people on the ground. It was Nigeria’s worst air crash in nearly two decades.

In March, a police helicopter carrying a high-ranking police official crashed in the central Nigerian city of Jos, killing four people.

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Chicano rock pioneers Los Lobos marking 40 years

LOS ANGELES (AP) — They are seen as the progenitors of Chicano rock ‘n’ roll, the first band that had the boldness, and some might even say the naiveté, to fuse punk rock with Mexican folk tunes.

It was a group called Los Lobos that had the unusual idea of putting an accordion, a saxophone and something called a bajo sexto alongside drums and Fender Stratocaster guitars and then blasting a ranchera-flavored folk tune or a Conjunto inspired melody through double reverb amps at about twice the volume you’d normally expect to hear.

“They were Latinos who weren’t afraid to break the mold of what’s expected and what’s traditionally played. That made them legendary, even to people who at first weren’t that familiar with their catalog,” said Greg Gonzalez of the young, Grammy-winning Latino-funk fusion band Grupo Fantasma.

To the guys in Los Lobos, however, the band that began to take shape some 40-odd years ago in the hallways of a barrio high school is still “just another band from East LA,” the words the group has used in the title of not one but two of its more than two dozen albums.

As a yearlong celebration of Los Lobos‘ 40th anniversary gets under way, having officially begun on Thanksgiving, much is likely to be made of how the band began as a humble mariachi group, toiling anonymously for nearly a decade at East LA weddings and backyard parties before the unlikely arrival of rock stardom.

That’s, well, sort of true.

For long before there was mariachi in Los Lobos‘ life, there was power-chord rock ‘n’ roll. Before the Latin trio Las Panchos had an impact, there was Jimi Hendrix.

“I actually went to go see him when I was 14 or 15,” says drummer-guitarist and principal lyricist Louie Perez, recalling how he had badgered his widowed mother to spend some of the hard-earned money she made sewing clothes in a sweatshop on a ticket to a Hendrix show.

“I sat right down front,” he recalls, his voice rising in excitement. “That experience just sort of rearranged my brain cells.”

About the same time, he had met a guitarist named David Hidalgo in an art class at James A. Garfield High, the school made famous in the 1988 film “Stand and Deliver” that profiled Jaime Escalante’s success in teaching college-level calculus to poor barrio kids. Soon the two had recruited fellow students Conrad Lozano and Cesar Rosas, both experienced musicians.

“Cesar had played in a power trio,” Perez recalls, while Lozano had been playing electric bass guitar for years.

It was sometime in November 1973 (no one remembers the exact day so they picked Thanksgiving) when the band is believed to have been born.

And the group might have stayed just another garage band from East LA, had it not been for a Mexican tradition called Las Mananitas.

“It’s a serenade to someone on their birthday,” Perez explains, and the group members’ mothers had birthdays coming up.

“So we learned about four or five Mexican songs and we went to our parents’ homes and did a little serenade,” Hidalgo recalled separately.

They were such a hit that they began scouring pawn shops for genuine Mexican instruments and really learning to play them.

Because they were at heart a rock ‘n’ roll band, however, they always played the music a little too loud and a little too fast. That was acceptable at the Mexican restaurants that employed them, until they decided to break out the Stratocaster guitars they had so coveted as kids.

“They said, ‘Well, that’s not what we hired you for,’” Perez says, chuckling.

So they headed west down the freeway to Hollywood, where initially the reaction wasn’t much better.

Saxophonist Steve Berlin recalls seeing the hybrid group showered with garbage one night when they opened for Public Image Ltd. Two years later, however, when they opened for Berlin’s group the Blasters, the reaction was different.

“It was quite literally an overnight success kind of thing,” the saxophonist recalls. “By the next morning, everybody I knew in Hollywood, all they were talking about was this band Los Lobos.”

A few nights later, they asked Berlin if he might jam with them. They were working up some tunes melding punk rock with Norteno, a Latin music genre that uses an accordion and a saxophone, and they needed a sax player.

For his part, Berlin says, he had never heard of Norteno music.

Something clicked, however, and soon he was producing the group’s first true rock album, 1984′s “How Will the Wolf Survive?” At the end of the sessions he was in the band.

The next 28 years would be pretty much the same kind of up-and-down ride as the first 12 were.

The group became international rock stars in 1987 with their version of the Mexican folk tune “La Bamba” for the soundtrack of the film of the same name. They melded 1950s teen idol Ritchie Valens’ rock interpretation with the original Son Jarocho style and sent the song to No. 1.

A two-year tour and a couple albums that nobody bought followed, leaving the group broke and disillusioned.

So they poured their anger and disillusionment into the lyrics and power chords of “Kiko,” the 1992 album now hailed as their masterpiece. A new version, recorded live, was released earlier this year.

The influence of Los Lobos‘ cross-cultural work can be heard to this day in the music of such varied young Latino groups as the hip-hop rockers Ozomatli, the Son Jarocho-influenced alt-music band Las Cafeteras and the Latino pop-rock group La Santa Cecilia, says Josh Kun, an expert on cross-border music.

“All of these bands inherited, wittingly or not, the experimental and style crossing instincts that Los Lobos proved were possible while hanging onto and developing your roots as a Mexican-American group,” said Kun, who curated the Grammy Museum’s recent “Trouble in Paradise” exhibition that chronicled the modern history of LA music.

For Los Lobos, winner of three Grammys, that was just the natural way of doing things for guys, Perez says, who learned early on that they didn’t fit in completely on either side of the U.S.-Mexico border.

“As Mexican-Americans in the U.S. we’re not completely accepted on this side of the border. And then on the other side of the border it’s like, ‘Well, what are you?’” he mused.

“So if that’s the case,” he added brightly, “then, hey, we belong everywhere.”

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First Responders Face Haunting Memories

Police and paramedics who descended on the scene of the massacre at a Connecticut grade school face haunting memories and nightmares in the days and weeks to come, particularly if they have children of their own, experts say.

Twenty children and seven adults were killed Friday after a gunman opened fire at Sandy Hook Elementary School in Newtown, Conn. The shooter, identified as 20-year-old Adam Lanza, then killed himself.

“How the first responders react depends on how closely they identify with the victims,” said Dr. Charles Marmar, chair of psychiatry at NYU Langone Medical Center in New York City. “Let’s say somebody has a son or a daughter the same age as the victims — we know that makes a big difference.”

CLICK HERE for full coverage of the tragedy at the elementary school.

After the initial shock of such a violent attack fades, first responders sometimes struggle with flashbacks and sleep disturbances that can take a personal and professional toll.

Neal Schwieterman, a first responder at the 1999 Columbine massacre, still struggles with memories of what he saw there.

“Part of me is still missing from that day,” said Schwieterman, who was a sheriff’s deputy in his last week with the Jefferson County Police Department at the time. “I will never be the same.”

Alex von Kleydorff/AP Photo

Newtown Teacher Kept 1st Graders Calm During Massacre Watch Video

Newtown School Shooting: What to Tell Your Kids Watch Video

Schwieterman rushed to the scene where he evacuated eight carloads of wounded students.

“It’s a grieving process for everyone after this kind of thing, including first responders,” said Schwieterman, who sought counseling to cope with the harrowing day. “It took a complete toll on me, and rightfully so.”

Schwieterman was not a father at the time, but now has a 10-year-old daughter.

“I just can’t imagine,” he said of the Newtown shooting. “It rips your heart out.”

CLICK HERE for live updates on the Connecticut school shooting.

Experts say first responders are surprisingly resilient, with the vast majority recovering from the stress of a horrific scene within days or weeks.

“But some will continue to have symptoms, and those people will probably benefit from some form of counseling,” said Dr. Spencer Eth, a professor of clinical psychiatry at the University of Miami. “Unfortunately, when it comes to police, they sometimes try to act tough even when they’re feeling badly, and that’s an obstacle to getting the help they need to recover.”

The fact that most of the victims in Newtown were children, Eth said, could mean more first responders will need counseling.

“The shock and horror of seeing children killed is more personally distressing than almost any other situation they have to deal with,” he said, adding that first responders in many cases are also responsible for notifying families of the deceased. “Having to notify parents of their child’s death is among the most difficult things they have to do in their professional lives.”

With help, first responders can learn to cope. But they can never forget. Schwieterman, who is now the mayor of Paonia, Colo., still speaks of Columbine with a shaky voice, pausing often to gather himself. And when he heard about the Newtown shooting, he knew his phone would be ringing.

“I’ve had several family members call and ask if I’m doing OK,” he said. “That kind of support helps you through these things.”

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Police hope motive emerges from evidence in shooter's home

Conn. State police spokesman Lt. Paul Vance at Saturday morning's news conference. (Jason Sickles/Yahoo News)

NEWTOWN, CT - The Sandy Hook school principal and another staffer were killed after lunging at a gunman who forced his way inside to begin a deadly shooting spree, the regional school superintendent said Saturday.

The principal, Dawn Hochsprung, 47, and school psychologist Mary Sherlach, 56, died along with 4 other adults and 20 children in the second deadliest mass shooting in U.S. history. The alleged shooter, 20-year old Adam Lanza, was found dead at the scene, and his mother, Nancy Lanza, was discovered dead at their home.

Newtown school superintendent Janet Robinson told reporters that the two educators and other staff members had put themselves in harms way to protect children once it became clear the school was under siege.

"The teachers were really, really focused on saving their students," Robinson said.

Police on Saturday said evidence recovered at gunman Lanza's home may provide a motive for the massacre.

State police spokesman Lt. Paul Vance declined to provide specifics about the evidence but said, "we're hopeful it will paint a complete picture."

Authorities say Lanza  killed his mother at their home Friday morning before driving to Sandy Hook.

[Related: Follow the latest updates from our reporters in Newtown]

Armed with two semi-automatic pistols, Lanza rapidly sprayed bullets in hallways and classrooms. Lanza killed himself before police officers could reach him.

Lt. Vance said all the bodies were removed from the school overnight. A medical examiner is expected to release the names of the victims later today.

Police have assigned a trooper to support each victim's family in the days ahead. Vance asked reporters to respect the families' grief and privacy.

"This is an extremely heartbreaking thing for them to endure," Lt. Vance said.

Police were expected to release the names of the victims Saturday afternoon. Some names were already being disclosed by family members, including teachers Lauren Rousseau, 30, and Vicki Soto, 27.

It will likely take investigators two more days to process the school crime scene where it is believed Lanza fired as many as 100 rounds from his guns.

"It's going to be a slow, painstaking process," Lt. Vance said.

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NKorea rocket launch shows young leader as gambler

PYONGYANG, North Korea (AP) — A triumphant North Korea staged a mass rally of soldiers and civilians Friday to glorify the country’s young ruler, who took a big gamble this week in sending a satellite into orbit in defiance of international warnings.

Wednesday’s rocket launch came just eight months after a similar attempt ended in an embarrassing public failure, and just under a year after Kim Jong Un inherited power following his father’s death.

The surprising success of the launch may have earned Kim global condemnation, but at home the gamble paid off, at least in the short term. To his people, it made the 20-something Kim appear powerful, capable and determined in the face of foreign adversaries.

Tens of thousands of North Koreans, packed into snowy Kim Il Sung Square, clenched their fists in a unified show of resolve as a military band tooted horns and pounded on drums.

Huge red banners positioned in the square called on North Koreans to defend Kim Jong Un with their lives. They also paid homage to Kim Jong Un’s father, Kim Jong Il, and his grandfather, North Korean founder Kim Il Sung.

Pyongyang says the rocket put a crop and weather monitoring satellite into orbit. Much of the rest of the world sees it as a thinly disguised test of banned long-range missile technology. It could bring a fresh round of U.N. sanctions that would increase his country’s international isolation. At the same time, the success of the launch could strengthen North Korea’s military, the only entity that poses a potential threat to Kim’s rule.

The launch’s success, 14 years after North Korea’s first attempt, shows more than a little of the gambling spirit in the third Kim to rule North Korea since it became a country in 1948.

“North Korean officials will long be touting Kim Jong Un as a gutsy leader” who commanded the rocket launch despite being new to the job and young, said Kim Byung-ro, a North Korea specialist at Seoul National University in South Korea.

The propaganda machinery churned into action early Friday, with state media detailing how Kim Jong Un issued the order to fire off the rocket just days after scientists fretted over technical issues, ignoring the chorus of warnings from Washington to Moscow against a move likely to invite more sanctions.

Top officials followed Kim in shrugging off international condemnation.

Workers’ Party Secretary Kim Ki Nam told the crowd, bundled up against a winter chill in the heart of the capital, that “hostile forces” had dubbed the launch a missile test. He rejected the claim and called on North Koreans to stand their ground against the “cunning” critics.

North Korea called the satellite a gift to Kim Jong Il, who is said to have set the lofty goal of getting a satellite into space and then tapped his son to see it into fruition. The satellite, which North Korean scientists say is designed to send back data about crops and weather, was named Kwangmyongsong, or “Lode Star” — the nickname legendarily given to the elder Kim at birth.

Kim Jong Il died on Dec. 17, 2011, so to North Koreans, the successful launch is a tribute. State TV have been replaying video of the launch to “Song of Gen. Kim Jong Il.”

But it is the son who will bask in the glory, and face the international censure that may follow.

Even while he was being groomed to succeed his father, Kim Jong Un had been portrayed as championing science and technology as a way to lift North Korea out of decades of economic hardship.

“It makes me happy that our satellite is flying in space,” Pyongyang citizen Jong Sun Hui said as Friday’s ceremony came to a close and tens of thousands rushed into the streets, many linking arms as they went.

“The satellite launch demonstrated our strong power and the might of our science and technology once again,” she told The Associated Press. “And it also clearly testifies that a thriving nation is in our near future.”

Aside from winning him support from the people, the success of the launch helps his image as he works to consolidate power over a government crammed with elderly, old-school lieutenants of his father and grandfather, foreign analysts said.

Experts say that what is unclear, however, is whether Kim will continue to smoothly solidify power, steering clear of friction with the powerful military while dealing with the strong possibility of more crushing sanctions. The United Nations says North Korea already has a serious hunger problem.

“Certainly in the short run, this is an enormous boost to his prestige,” according to Marcus Noland, a North Korea analyst at the Peterson Institute for International Economics in Washington.

Noland, however, also mentioned the “Machiavellian argument” that this could cause future problems for Kim by significantly boosting the power of the military — “the only real threat to his rule.”

Successfully firing a rocket was so politically crucial for Kim at the onset of his rule that he allowed an April launch to go through even though it resulted in the collapse of a nascent food-aid-for-nuclear-freeze deal with the United States, said North Korea analyst Kim Yeon-su of Korea National Defense University in Seoul.

The launch success consolidates his image as heir to his father’s legacy. But it could end up deepening North Korea’s political and economic isolation, he said.

On Friday, the section at the rally reserved for foreign diplomats was noticeably sparse. U.N. officials and some European envoys stayed away from the celebration, as they did in April after the last launch.

Despite the success, experts say North Korea is years from even having a shot at developing reliable missiles that could bombard the American mainland and other distant targets.

North Korea will need larger and more dependable missiles, and more advanced nuclear weapons, to threaten U.S. shores, though it already poses a shorter-range missile threat to its neighbors.

The next big question is how the outside world will punish Pyongyang — and try to steer North Korea from what could come next: a nuclear test. In 2009, the North conducted an atomic explosion just weeks after a rocket launch.

Scott Snyder, a Korea specialist for the Council on Foreign Relations, wrote recently that North Korea‘s nuclear ambitions should inspire the U.S., China, South Korea and Japan to put aside their issues and focus on dealing with Pyongyang.

If there is a common threat that should galvanize regional cooperation, “it most certainly should be the prospect of a 30-year-old leader of a terrorized population with his finger on a nuclear trigger,” Snyder said.

____

Jon Chol Jin in Pyongyang, and Foster Klug and Sam Kim in Seoul, South Korea, contributed to this report. Follow Jean H. Lee on Twitter: (at)newsjean.

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Sony’s PlayStation 4 could lose to the next Xbox before it’s even released

I love all game consoles equally. My Xbox 360 is used equally as much as my PlayStation 3. The Wii — oh, I’ll just leave it at that. The current generation of consoles is all but over — 10-year life cycle be damned — and new consoles are rumored to be coming next fall. If not next fall, then in 2014. Whatever is the case, Sony (SNE) can’t afford to lag in third place again. Sure, the Xbox 360 and PS3 are neck-in-neck in global lifetime sales, and the Xbox 360 did have a one year head start, but coming off the disappointing PS Vita, “confidence is less high” that Sony will deliver a console next year in time to compete with Microsoft (MSFT), according to Kotaku.

[More from BGR: Has the iPhone peaked? Apple’s iPhone 4S seen outselling iPhone 5]

I want a new console just as much as any other gamer. There’s a reason people are still pouncing on those Wii U consoles and flipping them on eBay. Six years is unusually long for a console to still be kicking around.

[More from BGR: Apple execs said to be ‘seething’ over Google Maps praise]

According to the well-informed Stephen Totilo, Editor-in-Chief of Kotaku, the game blog that first broke news on the next-gen Xbox, Microsoft’s “Durango” is ”on the mark” and “Sony appears to inspire less confidence…due to the on-and-off troubles of the PlayStation 3 and the struggles of the Vita vs. how much lost confidence is due to any problems looming for PS4.“

Totilo says “confidence is high that the next Xbox will be out in time for next Christmas” and confidence is low that the PS4 will be right there on store shelves next to it.

The “on-and-off troubles of the PlayStation 3″ Totilo is referring to is the anchor that’s weighed the console down since launch: tougher development due to the Cell processor and less available RAM – 256MB vs. 512MB in the Xbox 360.

In the months before the PS3′s launch in 2006, Sony said the console would be the most powerful console ever created, and here we are six years later and multi-platform games on the console consistently end up being buggier and uglier than on the Xbox 360 in many cases. Cases in point: Skyrim, Mass Effect 3 and Call of Duty: Black Ops II.

Sony’s in a rut right now. It has the chops to build beautiful and powerful hardware that’s a developer’s dream (ex: PS Vita), but at the same time, it’s always launching after the competition nowadays.

If Sony’s learned any lessons in the last half a decade, it better apply them to the PS4. The console needs to offer next-level processing and graphics. It needs to be backward-compatible with PS3 games and play Blu-ray discs. It should be small and quiet. It should have a strong online platform, support a greater array of apps and most importantly be easy for developers to program for.

Game exclusives will always be important, but now that games are million-dollar productions, multi-platform will be where developers hope to reap back their costs.

With Microsoft said to be preparing an “Xbox 720″ and an “Xbox Lite,” Sony can’t make the mistake of launching late or pricing the console too high. A launch in spring of 2014 would mean Sony will miss Black Friday and Cyber Monday, the two biggest shopping days of the year that bring in massive sales.  Ceding sales and market share to Microsoft and Nintendo by launching late would be disastrous.

The PS3 screwed up too many times. At this point, the PS4 needs to be perfect out of the door.

This article was originally published by BGR

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Matt Damon fracking film in Berlin festival lineup

BERLIN (Reuters) – The Berlin film festival on Thursday announced the first movies of its 2013 lineup, and among the main competition entries will be U.S. director Gus Van Sant‘s drama starring Matt Damon and centering around the controversial shale gas industry.

“Promised Land” will have its international premiere at the annual cinema showcase, although it is scheduled to be launched first in the United States.

According to online reports, “The Bourne Identity” star Damon was originally down to direct the movie tackling the practice of hydraulic fracturing, or “fracking” for shale gas, which has raised concerns over its environmental impact.

The film reunites the actor and film maker after Van Sant directed Damon in the acclaimed 1997 drama “Good Will Hunting”.

Damon was nominated for a best actor Academy Award for his performance and won a screenplay Oscar along with co-writer Ben Affleck for a movie that helped launch their Hollywood careers.

Also in the main competition in Berlin is “Gloria”, directed by Chilean film maker Sebastian Lelio, Korean entry “Nobody’s Daughter Haewon” directed by Hong Sangsoo and Romanian picture “Child’s Pose” by Calin Peter Netzer.

There will be a world premiere for “Paradise: Hope”, the final installment of Austrian director Ulrich Seidl’s Paradise trilogy, while out of competition in Berlin is 3D animation film “The Croods”, featuring the voice of Nicolas Cage.

And under the Berlinale Special heading comes documentary “Redemption Impossible”.

The 63rd Berlin film festival runs from February 7-17.

(Reporting by Mike Collett-White, editing by Paul Casciato)

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Confused by medication guides? You’re not alone

NEW YORK (Reuters Health) – The information sheets that come stapled to certain prescriptions picked up at the pharmacy are too complex and difficult for people to understand, according to a new study.

“Anyone who’s seen these are not going to be surprised by the fact that they’re difficult to read,” said Michael Wolf, the study’s lead author and an associate professor at Northwestern University’s Feinberg School of Medicine in Chicago.

The U.S. Food and Drug Administration-approved medication guides are attached to drugs that the agency considers to have “serious and significant public health concerns,” according to the report.

Patients are supposed to read the guides before taking the drugs to learn about risks, side effects, potential interactions with other drugs and why the medication should be taken as prescribed.

“You want to make sure that message is effective. Otherwise it can do major harm,” Wolf told Reuters Health.

In previous studies, Wolf and his colleagues found several problems with the guides, including patients not understanding their content and – in many cases – not even receiving them along with their medication.

The number of drugs required to be accompanied by a so-called med guide increased from 40 in 2006 to 305 last year. That led the researchers to look into whether the guides had gotten easier to understand.

For the new study, the researchers first analyzed 185 medication guides in April 2010, which represented the majority of those available on the FDA’s website at the time.

On average, the guides were about 2,000 words long, none of the guides had a review section or brief summary and only one met “suitability” guidelines frequently used as the standard for medical education materials.

Then, Wolf and his colleagues asked 449 adults at two Chicago clinics to read three medication guides then answer a series of questions about the drugs, including how they should be stored and their possible side effects. The participants were allowed to refer back to the guides during the test and were not rushed to answer the questions.

On average, the participants were only able to correctly answer half of the questions.

People with the lowest literacy level did the worst, answering only about a quarter of all the questions correctly. That compared to people with the highest level of literacy, who answered about 65 percent of the questions correctly.

The researchers add, however, that the results are limited, because they only tested three medication guides and people may not pay as close attention to the material if they’re not actually taking the drugs.

But, Wolf said, in general people failed the test.

“It was highly educated and lowly educated people. It didn’t make a difference. Everyone struggled,” said Wolf.

In their analysis, Wolf and his colleagues found the guides were typically written for someone at an 11th or 10th grade reading level.

They write in the Journal of General Internal Medicine that the Plain Writing Act of 2010 requires federal agencies to make information available to the public in a clear and understandable way. The Act, however, does not provide a way to measure what is understandable.

Some researchers have suggested that materials be written for people with a 4th to 8th grade reading level.

“If you’ve ever tried to create things at a 4th grade reading level, it’s incredibly difficult. And I don’t know if the evidence is clear as to what grade level is the target,” said Wolf.

There are a few possible solutions to the problem, including creating a uniform guide, which the researchers say is something the pharmaceutical industry and a private institution are working together to develop.

Wolf told Reuters Health that his team is also working with the U.S. Agency for Healthcare Research and Quality to create a how-to guide for medical organizations to make educational materials easy to understand.

He added that they’re also testing a new medication guide prototype in a clinical trial.

Until better guides become available, Wolf said patients should not be afraid to ask their doctors and pharmacists questions.

“Have that conversation when they’re getting it prescribed to them, but understand the pharmacist is available,” he said.

The FDA did not respond to a request for comment.

SOURCE: http://bit.ly/Y19pZ0 Journal of General Internal Medicine, online December 2012.

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20 children, 6 adults killed at Conn. school shooting

Twenty children died today when a heavily armed man invaded a Newtown,
Conn., elementary school and sprayed staff and students with bullets.

The gunman, identified as Adam Lanza, 20, was found dead in the school.

Lt. Paul Vance said 18 children died in the school and two more died
later in a hospital. Six adults were also slain, bringing the total to
26.

In addition to the casualties at the school, a body was also found in the shooter's home, officials said.

Among the dead was Lanza's mother, although it's not clear where she was killed.

In the early confusion surrounding the investigation, federal sources
initially identified the suspect as Adam's older brother Ryan Lanza, 24.
He is being questioned by police.

LIVE UPDATES: Newtown, Conn., School Shooting

Sources said the shooter was armed with a Glock semi automatic handgun
and a Sig Sauer semi automatic handgun, law enforcement sources told ABC
News. Additionally, .223 caliber shell casings--a rifle caliber--were
also found at the scene. He was wearing a bullet-proof vest when he
opened fire in the elementary school.

First grade teacher Kaitlin Roig, 29, locked her 14 students in a class
bathroom and listened to "tons of shooting" until police came to help.

"It was horrific," Roig said. "I thought we were going to die."

She said that the terrified kids were saying, "I just want Christmas…I don't want to die. I just want to have Christmas."

A tearful President Obama said there's "not a parent in America who doesn't feel the overwhelming grief that I do."

The president had to pause to compose himself after saying these were
"beautiful little kids between the ages of 5 and 10." As he continued
with his statement, Obama wiped away tears from each eye.

He has ordered flags flown as half staff.

The alert at the school ended when Vance announced, "The shooter is deceased inside the building. The public is not in danger."

The massacre prompted the town of Newtown to lock down all its schools
and draw SWAT teams to the school, authorities said today. Authorities
initially believed that there were two gunmen and were searching cars
around the school, but authorities do not appear to be looking for
another gunman.

It's unclear how many people have been shot, but 27 people, mostly
children, are dead, multiple federal and state sources tell ABC News.
That number could rise, officials said.

CLICK HERE for more photos from the scene.

It is the second worst mass shooting in U.S. history, exceeded only by
the Virginia Tech shooting in 2007 when 32 were killed before the
shooter turned the gun on himself. Today's carnage exceeds the 1999
Columbine High School shooting in which 13 died and 24 were injured.

The Newtown shooting comes three days after masked gunman Jacob Roberts
opened fire in a busy Oregon mall, killing two before turning the gun
on himself.

Today's shooting occurred at the Sandy Hook Elementary School, which
includes 450 students in grades K-4. The town is located about 12 miles
east of Danbury.

State Police received the first 911 call at 9:41 a.m. and immediately
began sending emergency units from the western part of the state.
Initial 911 calls stated that multiple students were trapped in a
classroom, possibly with a gunman, according to a Connecticut State
Police source.

Lt. Paul Vance said that on-duty and off-duty officers swarmed to the
school and quickly checked "every door, every crack, every crevice" in
the building looking for the gunman and evacuating children.

A photo from the scene shows a line of distressed children being led out of the school.

Three patients have been taken to Danbury Hospital, which is also on lockdown, according to the hospital's Facebook page.

"Out of abundance of caution and not because of any direct threat
Danbury Hospital is under lockdown," the statement said. "This allows us
simply to focus on the important work at hand."

Newtown Public School District secretary of superintendent Kathy June
said in a statement that the district's schools were locked down because
of the report of a shooting. "The district is taking preventive
measures by putting all schools in lockdown until we ensure the safety
of all students and staff," she said.

State police sent SWAT team units to Newtown.

All public and private schools in the town were on lockdown.

"We have increased our police presence at all Danbury Public Schools due
to the events in Newtown. Pray for the victims," Newtown Mayor Boughton
tweeted.

State emergency management officials said ambulances and other units were also en route and staging near the school.

A message on the school district website says that all afternoon
kindergarten is cancelled today and there will be no midday bus runs.

Also Read

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Cuban lawmakers meet to consider economy, budget

HAVANA (AP) — Cuban lawmakers are holding the second of their twice-annual sessions with a year-end report expected on the state of the country’s economy.

Legislators are also to approve next year’s budget.

Cuban leaders have sometimes used the parliamentary gatherings to make important announcements or policy statements.

Observers will be watching for word on the progress of President Raul Castro‘s economic reform plan and efforts to promote younger leaders.

The unicameral parliament will reconvene in February with a new membership following elections. It is then expected to name Castro to another five-year term.

State-run media said Castro presided over Thursday’s session.

It was not open to international journalists.

Latin America News Headlines – Yahoo! News

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Verizon Offering $5 Shared 4G Plan for Samsung Galaxy Camera

Imagine the powerful Samsung Galaxy S III smartphone, except that it can’t make phone calls and its backplate has been replaced by a digital camera — handgrip, zoom lens, and all. That’s basically the Samsung Galaxy Camera in a nutshell, and whether it’s a small, awkwardly-shaped Android tablet or a digital camera that you can play Modern Combat 3 on depends on how you look at it.

When the Galaxy Camera launched last month, it was only available in white, and cost $ 499 on AT&T’s network with a month-to-month data plan. But on Dec. 13, it launches on Verizon’s network, in both white and black. The Verizon Galaxy Camera costs $ 50 more up front, but in return it has 4G LTE instead of HSPA+, and Verizon is offering a “promotional price” for the monthly charge: Only $ 5 to add it to a Share Everything plan, instead of the usual $ 10 tablet rate.

A 4G digital camera

While it’s capable of functioning as an Android tablet (or game machine), the biggest reason for the Samsung Galaxy Camera’s 4G wireless Internet is so it can automatically upload photos it takes. Apps such as Dropbox, Photobucket, and Ubuntu One offer a limited amount of online storage space for free, where the Galaxy Camera can save photos without anyone needing to tell it to. Those photos can then be accessed at home, or on a tablet or laptop.

Most smartphones are able to do this already, but few (with the possible exception of the Windows Phone powered Nokia Lumia 920) are able to take photos as high-quality as the Galaxy Camera’s.

Not as good of a deal as it sounds

Dropbox is offering two years’ worth of 50 GB of free online storage space for photos and videos, to anyone who buys a Samsung Galaxy Camera from AT&T or Verizon. (The regular free plan is only 2 GB.)

The problem is, you may need that much space. The photos taken by the Galaxy Camera’s 16 megapixel sensor take up a lot more space, at maximum resolution, than ordinary smartphone snapshots do. Those camera uploads can eat through a shared data plan, and with Verizon charging a $ 15 per GB overage fee (plus the $ 50 extra up-front on top of what AT&T charges) it may make up for the cheaper monthly cost.

On top of that, the Galaxy Camera’s photos are basically on par with a $ 199 digital camera’s — you pay a large premium to combine that kind of point-and-shoot with the hardware equivalent of a high-end smartphone.

It does run Android, though, right?

The Galaxy Camera uses Samsung‘s custom software for its camera app, and lacks a normal phone dialer app. Beyond that, though, it runs the same Android operating system found on smartphones, and can run all the same games and apps.

Some apps don’t work the same on the Galaxy Camera as they do on a smartphone, however. Apps which only run in portrait mode, for instance, require you to hold the camera sideways to use them (especially unpleasant when they’re camera apps). And while it can make voice and even video calls over Skype, it lacks a rear-facing camera or the kind of speaker you hold up close to your ear. So you may end up making speakerphone calls and filming the palm of your hand.

Jared Spurbeck is an open-source software enthusiast, who uses an Android phone and an Ubuntu laptop PC. He has been writing about technology and electronics since 2008.
Linux/Open Source News Headlines – Yahoo! News

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Documents: Prisoner plotted to kill Justin Bieber

LAS CRUCES, N.M. (AP) — An imprisoned man whose infatuation with Justin Bieber included a tattoo of the pop star on his leg has told investigators in New Mexico he hatched a plot to kill him.

Court documents in a New Mexico district court say Dana Martin told investigators he persuaded a man he met in prison and the man’s nephew to kill Bieber, Bieber’s bodyguard and two others not connected to the pop star.

He told investigators that Mark Staake and Tanner Ruane headed east, planning to be near a Bieber concert scheduled in New York City. They missed a turn and crossed into Canada from Vermont. Staake was arrested on an outstanding warrant. Ruane was arrested later.

The two men face multiple charges stemming for the alleged plot.

Entertainment News Headlines – Yahoo! News

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More pressure to justify cost of cancer drugs versus benefits

(Reuters) – Medical providers have begun to think more about cost, as well as safety and effectiveness, when they decide on cancer treatments.

In the past, pharmaceutical companies could launch a high-priced drug with little push back. But now, there is more pressure from insurers as well as doctors to justify using drugs that provide only incremental benefits. Products that offer clear-cut advances in treatment, however, still command premium prices.

The pressure on costs is likely to accelerate. The U.S. Affordable Care Act includes several provisions aimed at improving the value of healthcare, including paying hospitals for the quality of care rather than the quantity.

“It’s a sign of the times,” said Mark Mynhier, partner, healthcare industries advisory at PricewaterhouseCoopers PwC. “We are in fact in a significantly financially challenging environment.”

Four-fifths of U.S. health insurers recently polled by PwC now require evidence of cost savings or a clear clinical benefit to include new products on their lists of covered drugs.

Doctors at New York’s Memorial Sloan-Kettering Cancer Center decided in November not to use Zaltrap, a new $ 11,000 a month colon cancer drug, because it has a “modest” impact on survival, works no better than Avastin, a similar but cheaper competitor, and has worse side effects.

Sanofi SA, according to the hospital, responded by offering the drug to all health providers at a 50 percent discount to its wholesale price.

The Manhattan cancer center still does not include Zaltrap on its list of available drugs. Sanofi and Regeneron, which helped develop and also sells the drug, both declined to comment.

“In order to warrant the price, you are going to have to have better overall survival,” said Rhonda Greenapple, chief executive at Reimbursement Intelligence, a consulting firm specializing in medical reimbursement.

Linking value to patient outcomes – mainly a drug’s impact on survival – is particularly important in oncology, where treatment costs can total tens of thousands of dollars a year.

“In cases where there are co-pays, they really do effect the consumer,” Mynhier said. “Patients are saying ‘I can’t afford to pay 10 or 20 percent of a $ 100,000 therapy.’”

WellPoint Inc, the second-largest U.S. health insurer by market value, said it is increasing the amount it pays for less expensive generic cancer drugs as an incentive for doctors to use them.

PROFIT OPPORTUNITY FOR DOCTORS

Infused cancer medications are first purchased by doctors, who then bill insurers for reimbursement. That is different from pills and other oral drugs for which doctors typically write a prescription filled at a pharmacy.

The offer of a 50-percent discount to Zaltrap’s list price is a potential windfall for doctors. Patients, health insurers, the government or anyone else who pays healthcare bills would not see a benefit.

“At the very least it is an incentive for doctors to use the drug,” said Dr Leonard Saltz, chief of Memorial Sloan-Kettering’s gastrointestinal oncology service. “And I find that concerning.”

He noted that rebates and discounts for cancer drugs are not uncommon, but said this is the first time he is aware of a verbal across-the-board offer for a half-price discount.

The average U.S. oncologist, according to the Journal of Oncology Practice, generated revenue of nearly $ 5 million last year, of which drug costs accounted for nearly $ 3 million.

To combat the temptation of wider profit margins, health plans in recent years began reimbursing doctors for cancer drugs based on average sales prices, rather than wholesale prices. But for a new drug such as Zaltrap, reimbursement is based on the full list price until a sales track record is established.

WellPoint said it is raising reimbursements to independent oncologist on a range of generic chemotherapy drugs by as much as 140 percent.

“These drugs are the backbone of many therapies recommended by the National Comprehensive Cancer Network (NCCN) … and typically much less expensive than their brand counterparts,” said Jennifer Malin, WellPoint’s medical director oncology.

She said the goal is to shift the system away from what has been a largely drug-revenue based practice model, to one where oncologists are paid for providing good patient-centered care.

“The payers are looking at the quality data and demanding incremental value over existing products,” said Dan Mendelson, chief executive officer of consulting firm Avalere Health.

“COKE DIDN’T WORK, SO LET’S TRY PEPSI”

Zaltrap was approved in August by the Food and Drug Administration after a study found it improved survival, in combination with chemotherapy, by 1.4 months in colon cancer patients who had stopped responding to chemo.

That is the same benefit seen with Avastin, sold by Roche Holding AG for around $ 5,000 a month, or about half the price of Zaltrap.

NCCN guidelines say either one or the other drug should be used, not both, but Dr Saltz said most Zaltrap use is likely in patients who were already treated with Avastin – a practice that insurers will eventually stop.

“It’s like saying Coke didn’t work so let’s try Pepsi,” he said.

As scientists unravel the biological underpinnings of cancer cells, new targeted therapies are being developed, but the process is expensive.

Dr. Saltz said the solution might just be to walk away from drugs with small, incremental benefits.

“We simply can’t afford to pay these very, very large amounts for drugs that offer most people very small benefit,” Dr Saltz said. “We haven’t figured out how to rein it in.”

(Reporting By Deena Beasley in Los Angeles. Editing by Andre Grenon)

Medications/Drugs News Headlines – Yahoo! News

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Rice drops out of race for top State post

Susan Rice (Stephen Lam/Reuters)Susan Rice, the embattled U.S. ambassador for the U.N., withdrew her name on Thursday from consideration to be secretary of state.

"If nominated, I am now convinced that the confirmation process would be lengthy, disruptive and costly—to you and to our most pressing national and international priorities," Rice wrote in a letter to President Barack Obama, NBC News first reported.

Obama confirmed her withdrawal in a statement Thursday afternoon, saying, "While I deeply regret the unfair and misleading attacks on Susan Rice in recent weeks, her decision demonstrates the strength of her character, and an admirable commitment to rise above the politics of the moment to put our national interests first."

Talk of Rice being nominated to succeed Hillary Clinton stirred significant controversy due to Rice's role in the handling of the Sept. 11, 2012, attack on the U.S. Consulate in Benghazi, Libya.

Republicans accuse Rice of misleading the public about intelligence that indicated the attack was premeditated. (The White House has also been accused of ignoring requests for increased security at the embassy.)

Rice's withdrawal is a loss for the administration, which had staunchly defended Rice amid the criticism. It will be viewed as a win for Arizona Republican Sen. John McCain and other Republican senators who had vowed to block Rice's confirmation.

McCain spokesman Brian Rogers emailed Yahoo News to express that the senator "thanks Ambassador Rice for her service to the country and wishes her well. ... He will continue to seek all the facts about what happened before, during and after the attack on our consulate in Benghazi that killed four brave Americans."

Republican Sen. Lindsey Graham of South Carolina, another leading Rice detractor, declared in a statement on Thursday, "I respect Ambassador Rice's decision." Graham said Obama "has many talented people to choose from" to succeed Clinton.

Graham has accused the administration of stonewalling efforts to look into the Benghazi attack and vowed to keep "working diligently to get to the bottom of what happened."

Speculation regarding who will be chosen as the next secretary of state now shifts to Democratic Sen. John Kerry of Massachusetts.

Obama is expected to overhaul much of his foreign policy and national security teams for the coming term. Defense Secretary Leon Panetta is departing, the position of director of the CIA is open after the David Petraeus scandal, and Homeland Security Secretary Janet Napolitano is rumored to be looking to replace Attorney General Eric Holder.

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The Hobbit: Richard Armitage Talks Preparations For Playing Thorin Oakenshield

British actor Richard Armitage admitted it wasn’t a walk in the park to play a J.R.R. Tolkien character in Peter Jackson’s reimagining of “The Hobbit,” the first installment of which is on its way into theaters.

Upon touching down in New Zealand, where the trilogy was shot, the cast had a lot of character preparation to do.

PLAY IT NOW: Martin Freeman Discusses The Hobbit’s ‘Good Chemistry’ & Playing Bilbo Baggins

“We arrived in February 2011 and we went straight into a training program, which was called ‘Dwarf Bootcamp,’ which was literally boots — these huge boots. We learned how to walk, we wrestled with each other, we did archery together, we did sword fighting, hammer fighting, horse riding — everything you could possibly think of,” Richard, who plays Thorin Oakenshield in the film told Access Hollywood at the film’s junket.

In addition, the cast, which includes his former “Cold Feet” co-star James Nesbitt as Bofur, found ways to get to know each other better off set.

VIEW THE PHOTOS: The Hobbit: An Unexpected Journey — New York City Premiere

“We went round to each other’s houses and we cooked food together, we went to the pub and got drunk together, so there was an incredibly great bonding time between the dwarves,” he said.

Richard had plenty of experience sword fighting and horse riding in the BBC America series “Robin Hood,” but it was something else that came in handy during the long days on set.

“I’d done a number of shows where I’d had to use sword fighting and I’d also done horse riding. I’d also pulled guns out of my pocket. That was less useful,” he laughed, likely referring to his recent role in the PBS-import series “MI-5,” where he played a British spy. “But, yeah, you draw on everything. I’d worked at the Royal Shakespeare Company, so the vocal work was really useful to kind of pull that from there. I’d worked in a circus, there were… all sorts of things that were really useful, but the one thing that I do have — for lack of talent — is stamina and that’s the one thing I think everybody needed on this job.”

VIEW THE PHOTOS: Meet ‘The Hobbit’ Cast!

An imagination was useful also, but Richard said what turned out on the big screen was still wilder – and more beautiful – than he dreamed of.

“So many moments… Actually, apart from the eagles — which every single time I’ve seen this film absolutely blows my mind and I can barely keep the tears back and [it has] nothing to do with the pathos of the scene, just that feeling of flight moves me — is the throne of Aragorn, in the beginning of the prologue,” he told Access of the moment that moved him most. “When it got to [filming] that scene, I walked on and… it was just a green cross on the floor with a tiny green chair… [But in the film], they just made this incredible, almost space aged, sort of suspended seat in the middle of this stalagmite. It just blows my mind when I see that.”

VIEW THE PHOTOS: The Brit Pack: Hot Shots Of Stars From The UK!

“The Hobbit: An Unexpected Journey” hits theaters on December 14, 2012, followed by “The Hobbit: The Desolation of Smaug,” on December 13, 2013 and “The Hobbit: There and Back Again,” on July 18, 2014.

– Jolie Lash

Copyright 2012 by NBC Universal, Inc. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Australia / Antarctica News Headlines – Yahoo! News

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AP PHOTOS: Top 10 Search Trends of 2012

NEW YORK (AP) — From the tragic to the downright silly, millions of people searched the Web in 2012 to find out about a royal princess, the latest iPad, a record-breaking skydiver and the death of a pop star.

Google released its 12th annual “zeitgeist” report on Wednesday. The company calls it “an in-depth look at the spirit of the times as seen through the billions of searches on Google over the past year.”

Here’s an Associated Press photo gallery of the top ten trending searches of 2012.

Gadgets News Headlines – Yahoo! News

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“Lincoln,” “Les Miserables,” “Playbook” lead acting nominations

LOS ANGELES (Reuters) – Hollywood‘s actors cast their net wide on Wednesday, nominating performers from big awards contenders “Lincoln” and musical “Les Miserables” for Screen Actors Guild honors while also singling out the likes of Denzel Washington and Javier Bardem.

“Lincoln,” “Les Miserables” and comedy “Silver Linings Playbook” led the nominations for the SAG awards with four apiece, including the top prize of best movie ensemble cast.

Joining them with two nominations each were the cast of Iranian hostage drama “Argo” and, in a surprise choice, British comedy “The Best Exotic Marigold Hotel.”

The awards from the Screen Actors Guild are among the most-watched honors during Hollywood film awards season leading up to the Academy Awards because actors make up the largest voting group when the Oscars come around in February.

SAG voters focus on performances rather than directing and writing, meaning that action and effects-heavy films like “The Hobbit” are usually sidelined.

Consequently, SAG largely shunned the expected Oscar contender “Zero Dark Thirty” about the U.S. hunt for Osama bin Laden, giving it just one nomination for Jessica Chastain’s performance as a CIA agent.

But the latest James Bond blockbuster “Skyfall” made it onto SAG‘s list, with nominations for its stunt ensemble and Spanish actor Bardem’s supporting turn as blond-haired villain Silva.

Other perceived Oscar-worthy movies, including slavery era Western “Django Unchained,” went unmentioned, while cult drama “The Master” had just one nomination – for actor Philip Seymour Hoffman.

Nicole Kidman made the best supporting actress list for her turn in the steamy but little-seen independent movie “The Paperboy,” while Britain’s Helen Mirren was recognized for her portrayal of Alfred Hitchcock’s long-suffering wife in “Hitchcock.”

The SAG awards will be given out in Los Angeles on January 27 in a live telecast on the TBS and TNT networks.

Golden Globe nominations are announced on Thursday and Oscar nominations will be revealed on January 10.

‘LINCOLN’ PICKS UP STEAM

“Lincoln,” director Steven Spielberg’s well-reviewed film about U.S. President Abraham Lincoln‘s battle to outlaw slavery, has been picking up multiple accolades from U.S. critics in the busy Hollywood awards season.

On Wednesday, it brought SAG nominations for lead actor Daniel Day-Lewis and supporting actors Sally Field as his wife, and Tommy Lee Jones as powerful Congressman Thaddeus Stevens.

Hugh Jackman was nominated for best actor while Anne Hathaway is in the race for her supporting role in the movie adaptation of hit stage musical “Les Miserables.”

Other actors nominated on Wednesday included the stars of quirky comedy “Silver Linings Playbook” – Bradley Cooper, Jennifer Lawrence and Robert DeNiro. John Hawkes and Helen Hunt also have a stake, for playing a disabled man and his sex therapist in heart-warming independent movie “The Sessions.”

“Being recognized by your peers is something I could only dream of happening and to be included in this group of actors is not only humbling but quite frankly, surreal,” Cooper, a first-time SAG nominees, said in a statement.

Washington, a two-time Oscar winner, was nominated for playing an alcoholic pilot in “Flight,” a role that has been largely overlooked in early critics award.

Perhaps the biggest surprise on Wednesday was “The Best Exotic Marigold Hotel,” the story of a group of elderly Britons who retire to a ramshackle Indian hotel.

The film, which boasts a strong British cast including Judi Dench, Tom Wilkinson and Bill Nighy, had two nominations – best ensemble and best supporting actress for Maggie Smith.

Smith also was nominated in SAG‘s television category for her role as a sarcastic countess in period drama “Downton Abbey.”

The popular British show was among the picks for ensemble acting in the TV category.

Other TV drama nominations went to the casts of “Boardwalk Empire,” “Homeland,” “Mad Men” and “Breaking Bad.”

In TV comedy, old favorites “30 Rock,” “Glee,” “The Big Bang Theory,” “Modern Family,” “Nurse Jackie” and “The Office” were nominated for their ensemble casts.

(Editing by Xavier Briand and Bill Trott)

Movies News Headlines – Yahoo! News

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Lilly plans another study for Alzheimer’s drug

INDIANAPOLIS (AP) — Eli Lilly‘s experimental Alzheimer’s drug has flashed potential to help with mild cases of the disease, but patients and doctors will have to wait a few more years to learn whether regulators will allow the drugmaker to sell it.

Lilly said Wednesday that it will launch another late-stage study of the drug, solanezumab, no later than next year’s third quarter. The company’s stock slipped in midday trading.

The Indianapolis drugmaker said in August that the intravenous treatment failed to slow memory decline in two late-stage studies of about 1,000 patients each. But scientists saw a statistically significant slowing when they combined trial data. Pooled results found 34 percent less mental decline in mild Alzheimer’s patients compared with those on a fake treatment for 18 months.

Researchers also saw a statistically significant result when they examined a subgroup of patients with mild cases of Alzheimer’s disease.

Lilly will attempt to confirm that benefit in the new trial before it seeks U.S. regulatory approval, something analysts widely expected the drugmaker to do after it announced the initial results.

The additional study could help Lilly build a better case with U.S. regulators. But it will likely take a few years to learn the results. Researchers will have to measure over time a patient’s rate of cognitive decline, which involves the ability remember things.

Citi analyst Andrew Baum said in a research note the study will likely be completed by the second half of 2015. He expects the drug, if approved, to launch in 2017.

Eli Lilly and Co.’s share price fell $ 1.60, or 3.2 percent, to close at $ 49. It’s still up 16 percent since the company announced the initial results in August. Baum said Wednesday’s news helped shake out some of the “false hope” for a near-term approval of the drug that had inflated the stock price.

Drugmakers have tried and failed for years to develop successful treatments for Alzheimer’s, and patients and doctors are anxious for something that can slow its progression.

Solanezumab was one of three potential Alzheimer’s drugs in late-stage testing. Bapineuzumab, being developed by Pfizer Inc. and Johnson & Johnson’s Janssen Alzheimer Immunotherapy unit, gave disappointing results in two studies last summer.

A pivotal study of the third — Gammagard, by Baxter International Inc. — will wrap up at the end of this year. Results are expected in the first or second quarter next year.

Solanezumab binds to beta-amyloid protein, which scientists believe is a key component to sticky plaque that basically gums up the brain of a patient with Alzheimer’s disease. The drug is designed to help the body remove the protein from the brain before it can form that plaque.

Current treatments like Pfizer Inc.’s Aricept try to control symptoms of the disease. Analysts have said a treatment that does more than manage symptoms such as memory loss, confusion and agitation could be worth billions of dollars in annual sales. But drugmakers first have to spend a massive amount on testing and clinical development to produce such a drug.

“When you go for the blockbuster, you have to pay for the blockbuster, either in money or time,” WBB Securities analyst Steve Brozak said regarding Lilly’s announcement.

More than 35 million people worldwide have dementia, a term for brain disorders that affect memory, judgment and other mental functions. Alzheimer’s is the most common type. Many Alzheimer’s patients typically live four to eight years after diagnosis, as the disease gradually erodes their memory and ability to think or perform simple tasks.

In the United States, 5.4 million people have Alzheimer’s, which is the country’s sixth-leading cause of death. The number of Alzheimer’s patients in the U.S. is expected to jump to 16 million by 2050, and costs for care are expected to skyrocket.

___

AP Chief Medical Writer Marilynn Marchione in Milwaukee contributed to this report.

Diseases/Conditions News Headlines – Yahoo! News

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Police: Mall shooting 'could have been much, much worse'

PORTLAND, Ore. (AP) — The gunman who killed two people and himself in a shooting rampage at an Oregon mall was 22 years old and used a stolen rifle from someone he knew, authorities said Wednesday.

Jacob Tyler Roberts had armed himself with an AR-15 semiautomatic rifle and had several fully loaded magazines when he arrived at a Portland mall on Tuesday, said Clackamas County Sheriff Craig Roberts.

The sheriff said the rifle jammed during the 22-year-old's attack, but he managed to get it working again. He later shot himself. Authorities don't yet have a motive but don't believe he was targeting specific people.

Two people — a 54-year-old woman and a 45-year-old man — were killed, and another, Kristina Shevchenko, 15, was wounded and in serious condition on Wednesday.

Roberts, wearing a hockey-style face mask, parked his 1996 green Volkswagen Jetta in front of the second-floor entrance to Macy's and walked briskly through the store, into the mall and began firing randomly, police said.

He fatally shot Steven Mathew Forsyth of West Linn and Cindy Ann Yuille of Portland, the sheriff said.

Roberts then fled along a mall corridor and into a back hallway, down stairs and into a corner where police found him dead from an apparent self-inflicted gunshot, authorities said.

People at the mall were heroic in helping get shoppers out of the building, including medical personnel who rendered aid, Roberts said.

In response to previous mass shootings elsewhere, the first arriving officers were trained to form teams and go inside instead of waiting for SWAT. Employees at the mall also received training to handle such a situation.

"This could have been much, much worse," Roberts said.

The first 911 call came at 3:29 p.m. Tuesday and officers arrived a minute later. By 3:51 p.m., all the victims and the gunman and rifle had been found. Four SWAT teams spent hours clearing the 1.4 million square-foot mall, leaving shoppers and workers to hide in fear.

Roberts rented a basement room in a modest, single-story Portland home and hadn't lived there long, said a neighbor, Bobbi Bates. Bates said she saw Roberts leave at 1:30 p.m. Tuesday wearing a dark jacket and jeans, carrying a guitar case. An occupant at the house declined to comment.

The mall Santa, Brance Wilson, was waiting for the next child's Christmas wish when shots rang out, causing the mall to erupt into chaos.

About to invite a child to hop onto his lap, Wilson instead dove for the floor and kept his head down as he heard shots being fired upstairs in the mall.

"I heard two shots and got out of the chair. I thought a red suit was a pretty good target," said Wilson, 68. Families waiting for Santa scattered. More shots followed, and Wilson crept away for better cover.

Witnesses heard the gunman saying, "I am the shooter," as he fired rounds from a semi-automatic rifle inside the Clackamas Town Center, a popular suburban mall several miles from downtown Portland.

Some were close enough to the shooter to feel the percussion of his gun.

Kayla Sprint, 18, was interviewing for a job at a clothing store when she heard shots.

"We heard people running back here screaming, yelling '911,'" she told The Associated Press.

Sprint barricaded herself in the store's back room until the coast was clear.

Jason DeCosta, a manager of a window-tinting company that has a display on the mall's ground floor, said when he arrived to relieve his co-worker, he heard shots ring out upstairs.

DeCosta ran up an escalator, past people who had dropped for cover and glass littering the floor.

"I figure if he's shooting a gun, he's gonna run out of bullets," DeCosta said, "and I'm gonna take him."

DeCosta said when he got to the food court, "I saw a gentleman face down, obviously shot in the head."

"A lot of blood," DeCosta said. "You could tell there was nothing you could do for him."

He said he also saw a woman on the floor who had been shot in the chest.

Austin Patty, 20, who works at Macy's, said he saw a man in a white mask carrying a rifle and wearing a bulletproof vest. There was a series of rapid-fire shots in short succession as Christmas music played. Patty said he dove for the floor and then ran.

His Macy's co-worker, Pam Moore, told the AP the gunman was short, with dark hair.

Kira Rowland told KGW-TV that she was shopping at Macy's with her infant son when the shots started.

"All of a sudden you hear two shots, which sounded like balloons popping," Rowland told the station. "Everybody got on the ground. I grabbed the baby from the stroller and got on the ground."

Rowland said she heard people screaming and crying.

"I put the baby back in the stroller and ran," Rowland said.

Kaelynn Keelin was working two stores down from Macy's when the gunfire began. She watched windows of another store get shot out. She and her co-workers ran to get customers inside their own store to take shelter.

"If we would have run out, we would have run right into it," she said.

Shaun Wik, 20, was Christmas shopping with his girlfriend and opened a fortune cookie at the food court. Inside was written: "Live for today. Remember yesterday. Think of tomorrow."

As he read it, he heard three shots. He heard a man he believes was the gunman shout, "Get down!" but Wik and his girlfriend ran. He heard seven or eight more shots. He didn't turn around.

"If I had looked back, I might not be standing here," Wik said. "I might have been one of the ones who got hit."

Clackamas Town Center is one of the Portland area's biggest and busiest malls, with 185 stores and a 20-screen movie theater.

Holli Bautista, 28, was shopping at Macy's for a Christmas dress for her daughter when she heard pops that sounded like firecrackers. "I heard people running and screaming and saying 'Get out, there's somebody shooting,'" she told the AP.

She said hundreds of shoppers and mall employees started running, and she and dozens of other people were trying to escape through a department store exit.

Tiffany Turgetto and her husband were leaving Macy's through the first floor when they heard gunshots coming from the second floor of the mall. They were able to leave quickly through a Barnes & Noble bookstore before the police locked down the mall.

"I had left my phone at home. I was telling people to call 911. Surprisingly, people are around me, no one was calling 911. I think people were in shock," she said.

___

Associated Press writers Steven DuBois, Nigel Duara, Anne M. Peterson, Tim Fought and Sarah Skidmore in Portland, Michelle Price in Phoenix, Pete Yost in Washington, Manuel Valdes in Seattle and researcher Rhonda Shafner contributed to this report.

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Corruption probe shrouds Quebec in new darkness

MONTREAL (Reuters) – Half a century ago, a new crop of Quebec leaders sparked the so-called Quiet Revolution to eradicate the “Great Darkness” – decades of corruption that kept Canada‘s French-speaking province under the dominance of one party and the Catholic church.

The revolution’s reforms, including cleaning up the way lawmakers were elected and secularizing the education system, seemed to work, paving the way for decades of growth, progress and prominence as Canada emerged as a model of democracy.

Fifty years later, a public inquiry into corruption and government bid-rigging suggests the province’s politics are not as clean as Quebecers had hoped or believed.

Since May, when the inquiry opened in Montreal, Canadians have been getting daily doses of revelations of fraud through live broadcasts on French-language television stations. Corruption involving the Mafia, construction bosses and politicians, the inquiry has shown, drove up the average building cost of municipal contracts by more than 30 percent in Montreal, Canada’s second-largest city.

Last month, Montreal Mayor Gerald Tremblay resigned as did the mayor of nearby Laval, Gilles Vaillancourt. Both denied doing anything wrong, but said they could not govern amid the accusations of corruption involving rigging of municipal contracts, kickbacks from the contracts and illegal financing of elections.

Tremblay has not been charged by police. Vaillancourt’s homes and offices have been raided several times by Quebec’s anti-corruption squad, which operates independently of the inquiry, but no charges have been filed against him either. Police said the raids were part of an investigation but they would not release further details.

“Quebecers lived for several years under the impression that they had found the right formula, that their parties were clean,” said Pierre Martin, political science professor at the University of Montreal. Now, he said, “people at all levels are fed up.”

The inquiry must submit its final report to the Quebec government by next October. It has exposed practices worthy of a Hollywood noir thriller – a mob boss stuffing his socks with money, rigged construction contracts, call girls offered as gifts, and a party fundraiser with so much cash he could not close the door of his safe.

“Even though we are in the early days, what is emerging is a pretty troubling portrait of the way public contracts were awarded,” said Antonia Maioni, director of the McGill Institute for the Study of Canada in Montreal.

Quebec’s Liberals, the force behind the Quiet Revolution, launched the inquiry as rumors of corruption swirled. The government then called an election for September, a year ahead of schedule, in what was seen as an attempt to stop damaging testimony hurting its popularity.

The tactic did not help. Jean Charest’s Liberals lost to the Parti Quebecois, whose ultimate aim is to take the French-speaking province, the size of Western Europe, out of Canada.

‘IT WASN’T COMPLICATED’

According to allegations at the inquiry, the corruption helped three main entities: the construction bosses who colluded to bid on contracts, the Montreal Mafia dons who swooped in for their share, and the municipal politicians who received kickbacks to finance campaigns.

In Quebec, the Mafia has been dominated by the Rizzuto family, with tentacles to the rest of Canada and crime families in New York and abroad. But recently the syndicate has been facing challenges from other crime groups in Montreal, according to the Toronto-based Mafia analyst and author Antonio Nicaso.

The reputed godfather of the syndicate, Vito Rizzuto, has been subpoenaed to appear before the commission, but the date for his testimony has not been set.

The hearings have zeroed in on four construction bosses and how their companies worked with the Mafia, bribed municipal engineers and provided funds for mayoralty campaigns in Montreal, the business capital for Quebec’s 8 million people.

“It’s not good for the economy,” said Martin. “It’s not good for any kind of legitimate business that tries to enter into any kind of long-term relationship with the public sector.”

Quebec’s anti-corruption squad has arrested 35 people so far this year, staging well-publicized raids on mayoral offices and on construction and engineering companies. The squad has arrested civil servants and owners of construction companies, among others.

“I now must suffer an unbearable injustice,” Tremblay said in a somber resignation speech earlier this month after a decade as mayor of Montreal, saying he could not continue in office because the allegations of corruption were causing a paralysis at City Hall.

Some of the most explosive allegations at the inquiry, headed by Quebec Superior Court Justice France Charbonneau, came from Lino Zambito, owner of a now bankrupt construction company, and from a top worker for Tremblay’s political party, Union Montreal.

Zambito, who is seen as one of the smaller players and who also faces fraud charges, described a system of collusion between organized crime, business cartels and corrupt civil servants, with payments made according to a predetermined formula.

“The entrepreneurs made money, and there was an amount that was due to the Mafia,” Zambito told the inquiry. “It wasn’t complicated.”

Zambito said the Mafia got 2.5 percent of the value of a contract, 3 percent went to Union Montreal and 1 percent to the engineer tasked with inflating contract prices.

Tremblay did not respond to emails requesting comment on the allegations of corruption at city hall.

A former party organizer, Martin Dumont, alleged the mayor was aware of double bookkeeping used to hide illegal funding during a 2004 election.

Dumont said the mayor walked out of the room during a meeting that explained the double bookkeeping system, saying he did not want to know anything about it.

Dumont also described how he was called into the office of a fundraiser for Union Montreal to help close the door of a safe because it was too full of money.

“I think it was the largest amount I’d ever seen in my life,” Dumont said at the inquiry.

GOLF, HOCKEY, ESCORTS

The inquiry also saw videos linking construction company players with Mafia bosses. In one police surveillance video, a Mafia boss was seen stuffing cash into his socks.

A retired city of Montreal engineer, Gilles Surprenant, described how he first accepted a bribe in the late 1980s after being “intimidated” by a construction company owner. Over the years he said he accepted over $ 700,000 from the owners in return for inflating the price of the contracts.

Another retired engineer, Luc Leclerc, admitted to bagging half a million dollars for the same service. He said the system was well-known to many at city hall and simply part of the “business culture” in Montreal. He also got gifts and paid golf trips to the Caribbean with other businessmen and Mafia bosses.

Gilles Vezina, who is currently suspended from his job as a city engineer, concurred.

“It was part of our business relationships to get advantages like golf, hockey, Christmas gifts” from construction bosses, he told the inquiry in mid-November.

The gifts didn’t stop there. Vezina said he was twice offered the services of prostitutes from different construction bosses in the 1980s or early 1990s, which he said he refused.

The accusations are jarring for a country that prides itself on being one of the least corrupt places in the world, according to corruption watchdog Transparency International. But experts say corruption in Montreal was something of an open secret.

“The alarm signals have been going off here for 20 years and no one has done anything,” said Andre Cedilot, a former journalist who co-wrote a book on the Canadian Mafia.

Quebec’s new government has introduced legislation tasking the province’s securities regulator with vetting businesses vying for public contracts and allowing it to block companies that do not measure up.

Anti-corruption activist Jonathan Brun was not optimistic.

“You’ve got to use modern technology,” said Brun, a co-founder of Quebec Ouvert, a group that wants to make all information about contracts freely available rather than asking regulators to oversee individual companies. “You’ve got to change the entire system if you really want to fight corruption.”

(Writing by Russ Blinch; Editing by Janet Guttsman, Mary Milliken and Prudence Crowther)

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Obama election tweet most repeated but Olympics tops on Twitter

(Reuters) – An election victory tweet from President Barack Obama — “Four more years” with a picture of him hugging his wife — was the most retweeted ever, but the U.S. election was topped by the Olympics as the most tweeted event this year.

Obama’s tweet was retweeted (repeated) more than 810,000 times, Twitter said as it published a list of the most tweeted events in 2012. (http://2012.twitter.com/)

“Within hours, that Tweet simultaneously became the most retweeted of 2012, and the most retweeted ever. In fact, retweets of that simple message came from people in more than 200 countries around the world,” Twitter spokeswoman Rachael Horwitz said.

Twitter users were busiest during the final vote count for the presidential elections, sending 327,452 tweets per minute on election night on their way to a tally of 31 million election tweets for the day.

The 2012 Olympic Games in London had the most overall tweets of any event, with 150 million sent over the 16 days.

Usain Bolt’s golden win in the 200 meters topped 80,000 tweets per minute but he did not achieve the highest Olympic peak on Twitter. That was seen during the closing ceremony when 115,000 tweets per minute were sent as 1990s British pop band the Spice Girls performed.

Syria, where a bloody civil war still plays out, was the most talked about country in 2012 but sports and pop culture dominated the tally of tweets.

Behind Obama was pop star Justin Bieber. His tweet, “RIP Avalanna. i love you” sent when a six-year-old fan died from a rare form of brain cancer, was retweeted more than 220,000 times.

Third most repeated in 2012 was a profanity-laced tweet from Green Bay Packers NFL player TJ Lang, when he blasted a controversial call by a substitute referee officiating during a referee dispute. That was retweeted 98,000 times.

This was the third year running that the microblogging site published its top Twitter trends, offering a barometer to assess the biggest events in social media.

Superstorm Sandy, which slammed the densely populated U.S. East Coast in late October, killing more than 100 people, flooding wide areas and knocking out power for millions, attracted more than 20 million tweets between October 27 and November 1.

European football made the list of top tweets when Spain’s Juan Mata scored as his side downed Italy 4-0 in the Euro 2012 final — sparking 267,200 tweets a minute.

News of pop star Whitney Houston‘s death in February generated more than 10 million tweets, peaking at 73,662 per minute.

Romantic comedy “Think Like a Man” was the most tweeted movie this year, topping “The Hunger Games”, “The Avengers” and “The Dark Knight Rises.”

Rapper Rick Ross who notched his fourth No. 1 album on the Billboard 200 chart this year, was the most talked about music artist.

(Editing by Rodney Joyce)

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“Hobbit” actor McKellen has prostate cancer

LONDON (Reuters) – “The Hobbit” actor Ian McKellen said in an interview published on Tuesday that he had had prostate cancer for the last six or seven years, but added that the disease was not life-threatening.

McKellen, 73, played Gandalf in the hit “Lord of the Rings” movie trilogy, and reprises the role in three prequels based on J.R.R. Tolkien’s novel “The Hobbit”.

The first of those, “The Hobbit: An Unexpected Journey”, recently had its world premiere in New Zealand, where it was shot under the directorship of Peter Jackson.

“I’ve had prostate cancer for six or seven years,” McKellen told the Daily Mirror tabloid. “When you have got it you monitor it and you have to be careful it doesn’t spread. But if it is contained in the prostate it’s no big deal.”

His representatives in London were not immediately available to comment on the interview.

“Many, many men die from it but it’s one of the cancers that is totally treatable,” added McKellen, one of Britain’s most respected actors who is also well known in Hollywood for appearances in the X-Men franchise.

“I am examined regularly and it’s just contained, it’s not spreading. I’ve not had any treatment.”

He admitted he feared the worst when he heard he had the disease.

“You do gulp when you hear the news. It’s like when you go for an HIV test, you go ‘arghhh is this the end of the road?’

“I have heard of people dying from prostate cancer, and they are the unlucky ones, the people who didn’t know they had got it and it went on the rampage. But at my age if it is diagnosed it’s not life threatening.”

“The Hobbit” opens in cinemas later this week.

(Reporting by Mike Collett-White)

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Boehner stands firm but hopeful on “fiscal cliff” talks

WASHINGTON (Reuters) – House of Representatives Speaker John Boehner offered no concrete signs of progress on Tuesday on the “fiscal cliff” talks but said he remained hopeful that both sides would reach an agreement by the end-of-year deadline.

Amid signs the White House and Boehner‘s office are making headway in the talks, Boehner repeated his now-familiar call for President Barack Obama to offer a new proposal to avert the automatic steep tax hikes and spending cuts set for the end of the year unless Congress intervenes.

“I’m an optimist. I’m hopeful we can reach an agreement,” Boehner said on the House floor.

While Boehner demanded more specific spending cuts from Obama, White House spokesman Jay Carney said the administration had submitted extensive proposals to reduce spending but Republicans had not offered specifics on increasing revenues.

“There is a deal out there that’s possible,” Carney told reporters. It could include reduced spending, more revenues and tax reform as long as Republicans accepted higher tax rates on the wealthiest Americans, he said.

“We do believe the parameters of a compromise are pretty clear,” Carney said.

The pace of staff-level talks has quickened since Boehner met on Sunday with Obama at the White House in a meeting that the Republican described as “nice” and “cordial.”

But Senate Democratic leader Harry Reid said it would be difficult to reach an agreement before Christmas.

“Until we hear something from Republicans, there’s nothing to draft,” Reid told reporters, referring to writing legislation based on a deal. “It’s going to be extremely difficult to get it done before Christmas.”

The two major elements of the fiscal cliff are broad spending reductions starting January 1 and tax cuts that expire at the end of the year. Economists have warned the fragile economy could slip back into recession without a deal.

Obama and Boehner have exchanged opening proposals aimed at cutting deficits by more than $ 4 trillion over the next 10 years, but they differ on how to get there.

Obama and Democrats demand that tax rates rise for the wealthiest 2 percent of Americans. Republicans want existing lower rates continued for all brackets and prefer to raise more revenue by eliminating tax loopholes and reducing deductions.

Republicans also want deeper spending cuts than those sought by Obama and fellow Democrats, particularly on social entitlement programs like the government-funded Medicare and Medicaid healthcare plans.

Stocks rose on Tuesday, with the S&P 500 reaching its highest close since Election Day. Markets endured a sharp selloff after the November 6 re-election of Obama, as investors focused on the fiscal cliff concerns.

“I guess in our own dysfunctional way, there is progress,” said Frank Davis, director of sales and trading at LEK Securities in New York. “Since conversations are occurring, it clarifies at least they are taking some action. My personal gut is they’ll jostle this into the holiday week and try to do a last-minute push.”

FRAMEWORK FOR A DEAL

While senior figures from both parties caution they are far from a deal, a softening of partisan rhetoric in recent days and the increased frequency of talks has created speculation that negotiations are going well.

If there is a fiscal cliff deal, congressional leaders will have to decide the most efficient way to move the controversial legislation forward. Aides said those decisions had not yet been made as negotiators were still focused on the elements of a possible deal and would then figure out the legislative vehicle to carry out any fiscal cliff measure.

The most frequently discussed scenario on Capitol Hill involves Democrats getting the higher rates on the top earners in exchange for significant concessions on reducing costs in entitlement programs.

The two parties could then work together next year on comprehensive tax reform aimed at creating more revenues, in part by eliminating some tax breaks.

A group of corporate leaders urged a fiscal cliff compromise that would include both higher taxes and spending cuts, but it did not take sides on whether the revenues should be from raising taxes on the wealthiest, as Obama wants, or from limiting deductions and closing loopholes, as Republicans want.

“For far too long, political paralysis has fueled global uncertainty that discourages businesses from investing and hiring new workers,” the CEOs said in a letter sent under the umbrella of the Business Roundtable, a non-partisan group that promotes business.

Complicating the talks is the looming need for an increase in U.S. borrowing authority that Obama wants before Congress wraps up for the year. Without the authority, the government will hit its $ 16.4 trillion borrowing limit by year’s end and run out of steps to stave off default by mid-February.

Obama has asked for the power to raise U.S. borrowing authority without legislation from Congress in hopes of avoiding another confrontation with Republicans like the 2011 showdown that led to an embarrassing downgrade of the U.S. credit rating.

Also in the mix is a payroll tax “holiday” set to expire, which, if not extended, will quickly reduce the take-home pay of a large segment of the U.S. workforce.

The holiday, now in its second year, has been providing workers with an average of about $ 1,000 a year in extra cash. Significant divisions remain on the payroll tax question in part because it funds the Social Security retirement program.

The payroll tax is paid by employers and employees each at a rate of 6.2 percent of wages, up to a maximum of $ 110,110. The holiday, enacted in 2010, reduced the rate by 2 percentage points on the portion paid by the worker.

Democratic Representative Chris Van Hollen said Republicans were coming around on the tax-rate hikes on the wealthiest Americans and there was a good chance of resolving that soon. But the other things might have to wait, he said, mentioning the budget cuts and the payroll tax.

If not complete by January 1, he said, “my belief is you would get it done very soon” after the New Year, noting that the government has some flexibility on withholding taxes that could limit the immediate hit to taxpayers while negotiations continued into 2013.

(Additional reporting by Rachelle Younglai, Kim Dixon, Steve Holland and Matt Spetalnick; Writing by John Whitesides; Editing by Alistair Bell and Eric Beech)

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